Shenfu injection attenuates cardiac dysfunction and inhibits apoptosis in septic mice.

ABSTRACT:

Background

Cardiac dysfunction frequently occurs after sepsis and septic shock and contributes to multiple organ failure. Shenfu injection, a well-known Chinese medicine formulation, has recently been demonstrated to possess potential cardio-protective effects, although its effect and mechanism in sepsis-induced myocardial dysfunction remains unclear.

Methods

To investigate whether Shenfu injection could alleviate myocardial injury and improve cardiac function, a model of sepsis was induced by cecal ligation and puncture (CLP) surgery in C57BL/6 mice. Cardiac function, inflammatory factors, and apoptosis were evaluated in the myocardium.

Results

Our results showed that the survival and left ventricular function markedly declined when exposed to CLP compared with the s

SUBMITTER: Zhao L 

PROVIDER: S-EPMC9201198 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature