Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task.

ABSTRACT: Negative urgency describes the tendency for rash and impulsive behaviour during negative emotional states and has been linked to a number of psychiatric disorders. However, there has been limited research on negative urgency as an explanatory mechanism for impulsivity in experimental animals. Such research has important implications for elucidating the neurobiology of negative urgency and thereby the development of future therapeutic interventions. In this study, we investigated the effects of negative urgency using a partial reinforcement schedule to increase the frequency of non-rewarded (i.e. frustrative) trials in the five-choice serial reaction time task, a widely used task to assess visual attention and impulsivity. Using a Markov chain model to analyse trial-by-trial outcomes we fou

SUBMITTER: Toschi C 

PROVIDER: S-EPMC9201310 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature