A Molecular Analysis of Memory B Cell and Antibody Responses Against Plasmodium falciparum Merozoite Surface Protein 1 in Children and Adults From Uganda.

ABSTRACT: Memory B cells (MBCs) and plasma antibodies against Plasmodium falciparum (Pf) merozoite antigens are important components of the protective immune response against malaria. To gain understanding of how responses against Pf develop in these two arms of the humoral immune system, we evaluated MBC and antibody responses against the most abundant merozoite antigen, full-length Pf merozoite surface protein 1 (PfMSP1_FL), in individuals from a region in Uganda with high Pf transmission. Our results showed that PfMSP1_FL-specific B cells in adults with immunological protection against malaria were predominantly IgG⁺ classical MBCs, while children with incomplete protection mainly harbored IgM⁺ PfMSP1_FL-specif

SUBMITTER: Gonzales SJ 

PROVIDER: S-EPMC9201334 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature