OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.

ABSTRACT:

Background & aims

Eosinophils are the main inflammatory effector cells that damage gastrointestinal tissue in eosinophilic gastrointestinal diseases (EGIDs). Activation of the OX40 pathway aggravates allergic diseases, such as asthma, but it is not clear whether OX40 is expressed in eosinophils to regulate inflammation in EGIDs. In this study, we assessed the expression and effect of OX40 on eosinophils in WT and Ox40^-/- eosinophilic gastroenteritis (EGE) mice.

Methods

Eosinophil infiltration, ovalbumin (OVA)-specific Ig production, OX40 expression and inflammatory factor levels in the intestine and bone marrow (BM) were investigated to evaluate inflammation.

Results

We confirmed that OVA-challenged mice produced high levels of Ox40, Mbp, Ccl11, I

SUBMITTER: Xu L 

PROVIDER: S-EPMC9201343 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature