Single-cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancer.

ABSTRACT:

Background

Endometrial cancer (EC) is one of the most common gynecologic malignancies with increasing morbidity. Cell-cell and cell-matrix interactions within the tumour microenvironment (TME) exert a powerful influence over the progression of EC. Therefore, a comprehensive exploration of heterogeneity and intratumoral crosstalk is essential to elucidate the mechanisms driving EC progression and develop novel therapeutic approaches.

Methods

4 EC and 2 normal endometrium samples were applied for single-cell RNA sequencing (scRNA-seq) analysis. In addition, we also included the public database to explore the clinical benefits of the single cell analysis.

Results

9 types of cells were identified with specific expression of maker genes. Both the malignant epithelial cells

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9201371 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature