Criteria for Treatment Response in Myasthenia Gravis: Comparison Between Absolute Change and Improvement Percentage in Severity Scores.

ABSTRACT:

Background

The absolute change in the severity score between the baseline and pre-specified time frame (absolute criterion) was recommended as a criterion for myasthenia gravis (MG) treatment response. But heterogeneity of disease severity might dilute major changes in individual patients. The rationality of relative criterion (improvement percentage) had not been evaluated in treatment response in patients with MG.

Objectives

To investigate the consistency between an absolute criterion and a relative criterion in the evaluation of treatment response in patients with MG.

Methods

We retrospectively analyzed the treatment response to a 3-month standardized treatment protocol with only glucocorticoid in 257 MG patients native to immunological treatments. With the commonl

SUBMITTER: Li HY 

PROVIDER: S-EPMC9201395 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature