M⁶A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement.

ABSTRACT: Although previous studies have shown that an enriched environment (EE) promotes neurogenesis and alters DNA and histone modifications, it remains largely unknown whether an EE affects epitranscriptome in the context of neuronal development. Here, we showed that EE exposure enhanced the pool of adult neural stem/progenitor cells (aNSPCs) and promoted neuronal differentiation of aNSPCs. EE exposure also improved cognitive capabilities and altered the expression of genes relating to neuronal development, neurogenesis, and memory. N ⁶-Methyladenosine (m⁶A) immunoprecipitation combined with deep sequencing (MeRIP-seq) data analysis revealed that EE exposure increased the global level of m⁶A and led to differential m⁶A mRNA modification. Differe

SUBMITTER: Qu W 

PROVIDER: S-EPMC9201454 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature