Identification of key miRNAs and targeted genes involved in the progression of oral squamous cell carcinoma.

ABSTRACT:

Background/purpose

Oral squamous cell carcinoma (OSCC) is one of the most common types of head and neck squamous cell carcinoma. Accurate biomarkers are needed for early diagnosis and prognosis of OSCC. MicroRNAs (miRNAs) have shown great values in different types of cancers including OSCC. However, most of the miRNAs involved in the development of OSCC remain uncovered. This study aimed to identify hub miRNAs and mRNAs in OSCC.

Materials and methods

We explored the roles of key miRNAs, target genes and their relationships in OSCC using an integrated bioinformatics approach. Initially, Two OSCC microarray datasets from the Gene Expression Omnibus database were obtained to analyze miRNA expression. MiRNA-targeted mRNAs were acquired, and gene ontology/kyoto encyclopedia of ge

SUBMITTER: Gu Y 

PROVIDER: S-EPMC9201551 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature