Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion.

ABSTRACT: Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex's role in motor behavior requires a mesoscopic-level description of the cortical regions engaged, their functional interactions, and how these functional interactions change with behavioral state. Mesoscopic Ca2+ imaging through transparent polymer skulls in mice reveals elevated activation of the dorsal cerebral cortex during locomotion. Using the correlations between the time series of Ca2+ fluorescence from 28 regions (nodes) obtained using spatial independent component analysis (sICA), we examined the changes in functional connectivity of the cortex from rest to locomotion with a goal of understanding the changes to the cortical functi

SUBMITTER: West SL 

PROVIDER: S-EPMC9201596 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature