Association of Leukocyte Adhesion and Rolling in Skin With Patient Outcomes After Hematopoietic Cell Transplantation Using Noninvasive Reflectance Confocal Videomicroscopy.

ABSTRACT:

Importance

Hematopoietic cell transplantation (HCT) is a potential cure for hematologic cancer but is associated with a risk of relapse and death. Dynamic biomarkers to predict relapse and inform treatment decisions after HCT are a major unmet clinical need.

Objective

To identify a quantitative characteristic of leukocyte-endothelial interactions after HCT and test its associations with patient outcomes.

Design, setting, and participants

In this prospective single-center cohort study from June 2017 to January 2020, patients of any age, sex, race, and ethnicity who had HCT for hematologic cancer were referred by health care professionals as either suspected of having symptoms or not having symptoms of acute graft-vs-host disease between 25 and 161 days after HCT. Patie

SUBMITTER: Saknite I 

PROVIDER: S-EPMC9201675 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature