Demographic and Methodological Heterogeneity in Electrocardiogram Signals From Guinea Pigs.

ABSTRACT: Electrocardiograms (ECG) are universally used to measure the electrical activity of the heart; however, variations in recording techniques and/or subject demographics can affect ECG interpretation. In this study, we investigated variables that are likely to influence ECG metric measurements in cardiovascular research, including recording technique, use of anesthesia, and animal model characteristics. Awake limb lead ECG recordings were collected in vivo from adult guinea pigs using a platform ECG system, while recordings in anesthetized animals were performed using both a platform and needle ECG system. We report significant heterogeneities in ECG metric values that are attributed to methodological differences (e.g., ECG lead configuration, ECG recording platform, presence or absenc

SUBMITTER: Haq KT 

PROVIDER: S-EPMC9202081 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature