The effect of HPV DNA and p16 status on the prognosis of patients with hypopharyngeal carcinoma: a meta-analysis.

ABSTRACT:

Objective

To evaluate whether the presence of human papillomavirus (HPV) DNA and p16 might be associated with better prognosis in patients with hypopharyngeal carcinoma (HPC), especially on overall survival (OS) and disease-free survival (DFS).

Method

PubMed, the Cochrane Library, the Web of Science and EMBASE were searched from inception to April 2021 to search for HPV DNA- and p16-related prognostic articles on HPC. Meta-analysis was performed on the selected articles according to the inclusion and exclusion criteria. Publication bias was assessed for the included studies with Egger's test. All studies were analyzed by using Stata 16.0 statistical software.

Results

A total of 18 studies were included, including 12 HPV DNA studies and 11 p16 studies. Meta-analysis sh

SUBMITTER: Shi J 

PROVIDER: S-EPMC9202146 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature