Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study.

ABSTRACT:

Background

Neonatal Opioid Withdrawal Syndrome (NOWS) is a significant public health issue and while millions of neonates are affected each year, an optimal pharmacologic weaning protocol has yet to be demonstrated. In this study, we compare hospital length of stay (LOS) and length of treatment (LOT) for treatment of neonatal opioid withdrawal (NOWS) with morphine versus methadone.

Methods

This was a single-site, open-label, randomized controlled pilot study conducted from October 2016-September 2018. Infants were eligible if their primary in-utero drug exposure was heroin, oral opioids, or methadone and they were born at greater than or equal to 34 weeks gestation. Infants were excluded for serious medical comorbidities and primary in-utero exposure to buprenorphine.

Res

SUBMITTER: Sutter MB 

PROVIDER: S-EPMC9202148 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature