FTO rs62033406 A>G associated with the risk of osteonecrosis of the femoral head among the Chinese Han population.

ABSTRACT:

Background

Fat mass and obesity-related (FTO) mRNA was downregulated in osteonecrosis patients. The study aimed to evaluate the correlation between FTO polymorphisms and the susceptibility of osteonecrosis of the femoral head (ONFH).

Methods

Six polymorphisms in FTO were genotyped via the Agena MassARRAY in 498 ONFH patients and 498 healthy controls. Multiple genetic models were used to assess the correlation between FTO polymorphisms and ONFH risk by SNPStats. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a logistic regression model adjusted by age, gender, smoking and drinking.

Results

The risk-increasing association of rs62033406 A>G with ONFH was found (OR = 1.25, 95% CI 1.05-1.50, p = 0.014). Specially, FTO rs62033406 A>G was related t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9202150 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature