MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice.

ABSTRACT:

Background

Lung ischemia-reperfusion injury (LIRI) is a cause of poor prognosis in several lung diseases and after lung transplantation. In LIRI, matrix metalloproteinases and pyroptosis indicators change in parallel, both of them involvement of inflammatory modulation, but it is unclear whether they are related to each other.

Methods

We analyzed the matrix metalloproteinases (MMPs) changes from RNA sequencing (RNA-Seq) data of human transplantation and rat ischemia-reperfusion lung tissues in the Group on Earth Observations (GEO) database. Then established the mouse LIRI model to validate the changes. Further, the severity of lung injury was measured after intervening the matrix metalloproteinases changes with their selective inhibitor during Lung ischemia-reperfusion. Mean

SUBMITTER: Zhou P 

PROVIDER: S-EPMC9202153 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature