GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression.

ABSTRACT:

Background

Growth differentiation factor-11 (GDF-11), also known as bone morphogenetic protein-11, belongs to the transforming growth factor-beta superfamily. GDF-11 was first identified as an important regulator during embryonic development. Increasing evidence has demonstrated that GDF-11 regulates the development of various organs and its aberrant expressions are associated with the risk of cardiovascular diseases and cancers. Extravillous trophoblast (EVT) cells invasion is a critical event for placenta development and needs to be finely regulated. However, to date, the biological function of GDF-11 in the human EVT cells remains unknown.

Methods

HTR-8/SVneo, a human EVT cell line, and primary cultures of human EVT cells were used to examine the effect of GDF-11 on matri

SUBMITTER: Wu Z 

PROVIDER: S-EPMC9202197 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature