Meta-matching as a simple framework to translate phenotypic predictive models from big to small data.

ABSTRACT: We propose a simple framework-meta-matching-to translate predictive models from large-scale datasets to new unseen non-brain-imaging phenotypes in small-scale studies. The key consideration is that a unique phenotype from a boutique study likely correlates with (but is not the same as) related phenotypes in some large-scale dataset. Meta-matching exploits these correlations to boost prediction in the boutique study. We apply meta-matching to predict non-brain-imaging phenotypes from resting-state functional connectivity. Using the UK Biobank (N = 36,848) and Human Connectome Project (HCP) (N = 1,019) datasets, we demonstrate that meta-matching can greatly boost the prediction of new phenotypes in small independent datasets in many scenarios. For example, translating a UK Biobank model to 1

SUBMITTER: He T 

PROVIDER: S-EPMC9202200 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature