HA gene amino acid mutations contribute to antigenic variation and immune escape of H9N2 influenza virus.

ABSTRACT: Based on differences in the amino acid sequence of the protein haemagglutinin (HA), the H9N2 avian influenza virus (H9N2 virus) has been clustered into multiple lineages, and its rapidly ongoing evolution increases the difficulties faced by prevention and control programs. The HA protein, a major antigenic protein, and the amino acid mutations that alter viral antigenicity in particular have always been of interest. Likewise, it has been well documented that some amino acid mutations in HA alter viral antigenicity in the H9N2 virus, but little has been reported regarding how these antibody escape mutations affect antigenic variation. In this study, we were able to identify 15 HA mutations that were potentially relevant to viral antigenic drift, and we also found that a key amino acid mutat

SUBMITTER: Zhu R 

PROVIDER: S-EPMC9202205 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature