Proteome analysis of urinary biomarkers in a cigarette smoke-induced COPD rat model.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease caused by inhalation of cigarette smoke (CS) and other harmful gases and particles.

Methods

This study aimed to explore potential urinary biomarkers for CS-induced COPD based on LC-MS/MS analysis.

Results

A total of 340 urinary proteins were identified, of which 79 were significantly changed (30, 31, and 37 at week 2, 4 and 8, respectively). GO annotation of the differential urinary proteins revealed that acute-phase response, response to organic cyclic compounds, complement activation classical pathway, and response to lead ion were significantly enriched at week 2 and 4. Another four processes were only enriched at week 8, namely response to oxidative stress, positive re

SUBMITTER: Qin W 

PROVIDER: S-EPMC9202220 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature