A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: Long-Term Observation of the Electrode-Tissue Interface.

ABSTRACT:

Purpose

To report the long-term observations of the electrode-tissue interface and perceptual stability in humans after chronic stimulation with a 44-channel suprachoroidal retinal implant.

Methods

Four subjects (S1-4) with end-stage retinitis pigmentosa received the implant unilaterally (NCT03406416). Electrode impedances, electrode-retina distance (measured using optical coherence tomography imaging), and perceptual thresholds were monitored up to 181 weeks after implantation as the subjects used the prosthesis in the laboratory and in daily life. Stimulation charge density was limited to 32 µC/cm2 per phase.

Results

Electrode impedances were stable longitudinally. The electrode-retina distances increased after surgery and then stabilized, and were well-described by

SUBMITTER: Titchener SA 

PROVIDER: S-EPMC9202334 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature