Changes in Adiposity and Cerebrospinal Fluid Biomarkers Following a Modified Mediterranean Ketogenic Diet in Older Adults at Risk for Alzheimer's Disease.

ABSTRACT:

Background

Ketogenic diets have been used to treat both obesity and neurological disorders, including epilepsy and more recently Alzheimer's disease (AD), likely due to favorable effects on both central and peripheral metabolism. Improvements in body composition have also been reported; however, it is unclear if diet-induced changes in adiposity are related to improvements in AD and related neuropathology.

Purpose

We examined the effects of a Modified Mediterranean Ketogenic (MMK) diet vs. an American Heart Association (AHA) diet on body weight, body composition, and body fat distribution and their association with cerebrospinal fluid (CSF) biomarkers in older adults at risk for AD.

Methods

Twenty adults (mean age: 64.3 ± 6.3 years, 35% Black, 75% female) were randoml

SUBMITTER: Brinkley TE 

PROVIDER: S-EPMC9202553 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature