Microneedle Aptamer-Based Sensors for Continuous, Real-Time Therapeutic Drug Monitoring.

ABSTRACT: The ability to continuously monitor the concentration of specific molecules in the body is a long-sought goal of biomedical research. For this purpose, interstitial fluid (ISF) was proposed as the ideal target biofluid because its composition can rapidly equilibrate with that of systemic blood, allowing the assessment of molecular concentrations that reflect full-body physiology. In the past, continuous monitoring in ISF was enabled by microneedle sensor arrays. Yet, benchmark microneedle sensors can only detect molecules that undergo redox reactions, which limits the ability to sense metabolites, biomarkers, and therapeutics that are not redox-active. To overcome this barrier, here, we expand the scope of these devices by demonstrating the first use of microneedle-supported electrochemica

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9202557 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature