Trypanosoma cruzi strain and starvation-driven mitochondrial RNA editing and transcriptome variability.

ABSTRACT: Trypanosoma cruzi is a unicellular protistan parasitic species that is comprised of strains and isolates exhibiting high levels of genetic and metabolic variability. In the insect vector, it is known to be highly responsive to starvation, a signal for progression to a life stage in which it can infect mammalian cells. Most mRNAs encoded in its mitochondrion require the targeted insertion and deletion of uridines to become translatable transcripts. This study defined differences in uridine-insertion/deletion RNA editing among three strains and established the mechanism whereby abundances of edited (and, thus, translatable) mitochondrial gene products increase during starvation. Our approach utilized our custom T-Aligner toolkit to describe transcriptome-wide editing events and recons

SUBMITTER: Gerasimov ES 

PROVIDER: S-EPMC9202582 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature