De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface.

ABSTRACT: Here we demonstrate that short peptides, de novo designed from first principles, self-assemble on the surface of graphite to produce a highly robust and catalytic nanoarchitecture, which promotes peroxidation reactions with activities that rival those of natural enzymes in both single and multi-substrate reactions. These designable peptides recapitulate the symmetry of the underlying graphite surface and act as molecular scaffolds to immobilize hemin molecules on the electrode in a hierarchical self-assembly manner. The highly ordered and uniform hybrid graphite-peptide-hemin nanoarchitecture shows the highest faradaic efficiency of any hybrid electrode reported. Given the explosive growth of the types of chemical reactions promoted by self-assembled peptide materials, this new appr

SUBMITTER: Luo W 

PROVIDER: S-EPMC9202597 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature