Maternal Testosterone Concentrations in Third Trimester and Offspring Handgrip Strength at 5 Years: Odense Child Cohort.

ABSTRACT:

Background

Maternal testosterone in pregnancy may have conditioning effects on offspring muscle strength.

Purpose

To investigate possible associations between maternal testosterone concentrations in third trimester and offspring handgrip strength (HGS) at 5 years.

Methods

In the prospective, population-based Odense Child Cohort, total testosterone (TT) at gestational week 27-28 and 5-year HGS were measured in 1017 mother-child pairs. TT was measured by liquid chromatography-tandem mass spectrometry and free testosterone (FT) was calculated from TT and sex hormone-binding globulin (SHBG). Multivariable regression analyses were performed with HGS < 10th percentile as cutoff for low HGS.

Results

Third-trimester FT concentration was 0.004 (0.002-0.007) nmol/L, geom

SUBMITTER: Dybdahl M 

PROVIDER: S-EPMC9202699 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature