SHBG, Bone Mineral Density, and Physical Function Among Injection Drug Users With and Without HIV and HCV.

ABSTRACT:

Context

Sex hormone-binding globulin (SHBG) is a glycoprotein that regulates the bioavailability of sex hormones and is higher in people with HIV (PWH) and hepatitis C virus (HCV). SHBG is associated with aging-related diseases, including osteoporosis and frailty in the general population. However, the relationship between SHBG concentration and bone mineral density (BMD) and physical function among PWH and HCV is unclear.

Objective

This study aimed to evaluate the association between chronic infection with HIV and HCV and SHBG, and to assess the relationship of circulating SHBG concentrations with low BMD, physical function impairment, and frailty.

Methods

A cross-sectional study was conducted of 278 HCV-exposed (HCV antibody positive) adults enrolled with and withou

SUBMITTER: Dias JP 

PROVIDER: S-EPMC9202730 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature