Augmented risk of dementia in hypertrophic cardiomyopathy: A propensity score matching analysis using the nationwide cohort.

ABSTRACT:

Background

Dementia is a big medical and socioeconomic problem on aging society, and cardiac diseases have already shown a significant contribution to developing dementia. However, the risk of dementia related to hypertrophic cardiomyopathy (HCM), the most common inherited cardiomyopathy, has never been evaluated.

Methods

In a large-scale longitudinal cohort using National Health Insurance database, 4,645 subjects with HCM aged ≥50 years between 2010 and 2016 were collected and matched with 13,935 controls, based on propensity scores (1:3). We investigated the incidence and risk of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) between groups.

Results

During follow-up (median 3.9 years after 1-year lag), incident dementia occurred in 739 subjects (4.0

SUBMITTER: Lee H 

PROVIDER: S-EPMC9202937 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature