Harm-to-Benefit of Three Decades of Prostate Cancer Screening in Black Men.

ABSTRACT:

Background

Prostate-specific antigen screening has profoundly affected the epidemiology of prostate cancer in the United States. Persistent racial disparities in outcomes for Black men warrant re-examination of the harms of screening relative to its cancer-specific mortality benefits in this population.

Methods

We estimated overdiagnoses and overtreatment of prostate cancer for men of all races and for Black men 50 to 84 years of age until 2016, the most recent year with treatment data available, using excess incidence relative to 1986 based on the Surveillance, Epidemiology, and End Results registry and U.S. Census data as well as an established microsimulation model of prostate cancer natural history. Combining estimates with plausible mortality benefit, we calculated numb

SUBMITTER: Basourakos SP 

PROVIDER: S-EPMC9202998 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature