Distinct representation of cue-outcome association by D1 and D2 neurons in the ventral striatum's olfactory tubercle.

ABSTRACT: Positive and negative associations acquired through olfactory experience are thought to be especially strong and long-lasting. The conserved direct olfactory sensory input to the ventral striatal olfactory tubercle (OT) and its convergence with dense dopaminergic input to the OT could underlie this privileged form of associative memory, but how this process occurs is not well understood. We imaged the activity of the two canonical types of striatal neurons, expressing D1- or D2-type dopamine receptors, in the OT at cellular resolution while mice learned odor-outcome associations ranging from aversive to rewarding. D1 and D2 neurons both responded to rewarding and aversive odors. D1 neurons in the OT robustly and bidirectionally represented odor valence, responding similarly to odors predic

SUBMITTER: Martiros N 

PROVIDER: S-EPMC9203051 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature