Self-organization of in vitro neuronal assemblies drives to complex network topology.

ABSTRACT: Activity-dependent self-organization plays an important role in the formation of specific and stereotyped connectivity patterns in neural circuits. By combining neuronal cultures, and tools with approaches from network neuroscience and information theory, we can study how complex network topology emerges from local neuronal interactions. We constructed effective connectivity networks using a transfer entropy analysis of spike trains recorded from rat embryo dissociated hippocampal neuron cultures between 6 and 35 days in vitro to investigate how the topology evolves during maturation. The methodology for constructing the networks considered the synapse delay and addressed the influence of firing rate and population bursts as well as spurious effects on the inference of connections. We foun

SUBMITTER: Antonello PC 

PROVIDER: S-EPMC9203058 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature