Current Steering Using Multiple Independent Current Control Deep Brain Stimulation Technology Results in Distinct Neurophysiological Responses in Parkinson's Disease Patients.

ABSTRACT:

Background

Deep brain stimulation (DBS) is an effective neuromodulation therapy to treat people with medication-refractory Parkinson's disease (PD). However, the neural networks affected by DBS are not yet fully understood. Recent studies show that stimulating on different DBS-contacts using a single current source results in distinct EEG-based evoked potentials (EPs), with a peak at 3 ms (P3) associated with dorsolateral subthalamic nucleus stimulation and a peak at 10 ms associated with substantia nigra stimulation. Multiple independent current control (MICC) technology allows the center of the electric field to be moved in between two adjacent DBS-contacts, offering a potential advantage in spatial precision.

Objective

Determine if MICC precision targeting results in dist

SUBMITTER: Peeters J 

PROVIDER: S-EPMC9203070 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature