The first study on opportunistic intestinal microsporidiosis in IBD patients receiving immunosuppressive medications in Iran.

ABSTRACT: Microsporida are known as opportunistic unicellular organisms and have recently been reclassified as fungi that have been frequently reported from patients with congenital and acquired immunity failure disorders, worldwide. However, use of immunosuppressive medications in inflammatory bowel disease (IBD) patients significantly decreases overall immunity, and increases their susceptibility to opportunistic infections. Totally, 71 stool samples were collected from IBD patients consisted of 69 ulcerative colitis (UC) patients and two Crohn's disease (CD) patients. All patients had taken immunosuppressive and/or immunomodulator drugs for at least 3 weeks. DNA was extracted from all stool samples and Nested PCR was performed using genus-specific primers based on small subunit ribosomal RNA (SSU

SUBMITTER: Hasani Z 

PROVIDER: S-EPMC9203424 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature