Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT.

ABSTRACT: Iron is essential for many biological processes, but iron levels must be tightly regulated to avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide association studies on four iron-related biomarkers (serum iron, serum ferritin, transferrin saturation, total iron-binding capacity) in the Trøndelag Health Study (HUNT), the Michigan Genomics Initiative (MGI), and the SardiNIA study, followed by their meta-analysis with publicly available summary statistics, analyzing up to 257,953 individuals. We identify 123 genetic loci associated with iron traits. Among 19 novel protein-altering variants, we observe a rare missense variant (rs367731784) in HUNT, which suggests a role for DNAJC13 in transferrin recycling. We further validate recently published results usi

SUBMITTER: Moksnes MR 

PROVIDER: S-EPMC9203493 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature