Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia.

ABSTRACT: Aging is a major risk factor for developing severe COVID-19, but few detailed data are available concerning immunological changes after infection in aged individuals. Here we describe main immune characteristics in 31 patients with severe SARS-CoV-2 infection who were >70 years old, compared to 33 subjects <60 years of age. Differences in plasma levels of 62 cytokines, landscape of peripheral blood mononuclear cells, T cell repertoire, transcriptome of central memory CD4⁺ T cells, specific antibodies are reported along with features of lung macrophages. Elderly subjects have higher levels of pro-inflammatory cytokines, more circulating plasmablasts, reduced plasmatic level of anti-S and anti-RBD IgG3 antibodies, lower proportions of central memory CD4⁺ T cells, more i

SUBMITTER: Lo Tartaro D 

PROVIDER: S-EPMC9203559 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature