The impact of species-wide gene expression variation on Caenorhabditis elegans complex traits.

ABSTRACT: Phenotypic variation in organism-level traits has been studied in Caenorhabditis elegans wild strains, but the impacts of differences in gene expression and the underlying regulatory mechanisms are largely unknown. Here, we use natural variation in gene expression to connect genetic variants to differences in organismal-level traits, including drug and toxicant responses. We perform transcriptomic analyses on 207 genetically distinct C. elegans wild strains to study natural regulatory variation of gene expression. Using this massive dataset, we perform genome-wide association mappings to investigate the genetic basis underlying gene expression variation and reveal complex genetic architectures. We find a large collection of hotspots enriched for expression quantitative trait loci across th

SUBMITTER: Zhang G 

PROVIDER: S-EPMC9203580 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature