Understanding the possible influence of Pumilio RNA binding proteins on terpenoid indole alkaloid biosynthesis in Catharanthus roseus.

ABSTRACT: Catharanthus roseus is a clinically significant medicinal plant; the sole source of chemotherapy agents, vincristine and vinblastine (specialized metabolites, terpenoid indole alkaloids/TIAs). Owing to large clinical demand and low bioavailability, several studies have focused on biosynthesis and regulation of TIA biosynthesis in C. roseus. However, transcription factor mediated regulation has been a major research focus, and the impact of post-transcriptional regulation remains under-explored. RNA binding proteins (RBPs) are an emerging class of post-transcriptional regulators having a profound influence on transcript stability. Pumilio (Pum) RBPs are evolutionarily conserved post-transcriptional regulators, involved in RNA degradation across eukaryotes. However, their poten

SUBMITTER: Nishanth MJ 

PROVIDER: S-EPMC9203614 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature