Glycomic biomarkers are instrumental for suboptimal health status management in the context of predictive, preventive, and personalized medicine.

ABSTRACT:

Objectives

Suboptimal health status (SHS), a reversible borderline condition between optimal health status and disease, has been recognized as a main risk factor for non-communicable diseases (NCDs). From the standpoint of predictive, preventive, and personalized medicine (PPPM/3PM), the early detection of SHS provides a window of opportunity for targeted prevention and personalized treatment of NCDs. Considering that immunoglobulin G (IgG) N-glycosylation levels are associated with NCDs, it can be speculated that IgG N-glycomic alteration might occur at the SHS stage.

Methods

A case-control study was performed and it consisted of 124 SHS individuals and 124 age-, gender-, and body mass index-matched healthy controls. The IgG N-glycan profiles of 248 plasma samples were anal

SUBMITTER: Meng X 

PROVIDER: S-EPMC9203619 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature