Integrative multi-omic analysis identifies genetically influenced DNA methylation biomarkers for breast and prostate cancers.

ABSTRACT: Aberrant DNA methylation has emerged as a hallmark in several cancers and contributes to risk, oncogenesis, progression, and prognosis. In this study, we performed imputation-based and conventional methylome-wide association analyses for breast cancer (BrCa) and prostate cancer (PrCa). The imputation-based approach identified DNA methylation at cytosine-phosphate-guanine sites (CpGs) associated with BrCa and PrCa risk utilising genome-wide association summary statistics (N_BrCa = 228,951, N_PrCa = 140,254) and prebuilt methylation prediction models, while the conventional approach identified CpG associations utilising TCGA and GEO experimental methylation data (N_BrCa = 621, N_PrCa = 241). Enrichment analysis of the association results implicated 77

SUBMITTER: Sathyanarayanan A 

PROVIDER: S-EPMC9203749 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature