Capturing additional genetic risk from family history for improved polygenic risk prediction.

ABSTRACT: Family history of complex traits may reflect transmitted rare pathogenic variants, intra-familial shared exposures to environmental and lifestyle factors, as well as a common genetic predisposition. We developed a latent factor model to quantify trait heritability in excess of that captured by a common variant-based polygenic risk score, but inferable from family history. For 941 children in the Avon Longitudinal Study of Parents and Children cohort, a joint predictor combining a polygenic risk score for height and mid-parental height was able to explain ^~55% of the total variance in sex-adjusted adult height z-scores, close to the estimated heritability. Marginal yet consistent risk prediction improvements were also achieved among ^~400,000 European ancestry participa

SUBMITTER: Lu T 

PROVIDER: S-EPMC9203758 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature