A spatiotemporal multi-scale computational model for FDG PET imaging at different stages of tumor growth and angiogenesis.

ABSTRACT: A deeper understanding of the tumor microenvironment (TME) and its role in metabolic activity at different stages of vascularized tumors can provide useful insights into cancer progression and better support clinical assessments. In this study, a robust and comprehensive multi-scale computational model for spatiotemporal transport of F-18 fluorodeoxyglucose (FDG) is developed to incorporate important aspects of the TME, spanning subcellular-, cellular-, and tissue-level scales. Our mathematical model includes biophysiological details, such as radiopharmaceutical transport within interstitial space via convection and diffusion mechanisms, radiopharmaceutical exchange between intracellular and extracellular matrices by glucose transporters, cellular uptake of radiopharmaceutical, as well as

SUBMITTER: Kashkooli FM 

PROVIDER: S-EPMC9203789 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature