Integrated analysis reveals the pivotal interactions between immune cells in the melanoma tumor microenvironment.

ABSTRACT: Melanoma is the most lethal type of skin cancer. Despite the breakthroughs in the clinical treatment of melanoma using tumor immunotherapy, many patients do not benefit from these immunotherapies because of multiple immunosuppressive mechanisms. Therefore, there is an urgent need to determine the mechanisms of tumor-immune system interactions and their molecular determinants to improve cancer immunotherapy. In this study, combined analysis of microarray data and single-cell RNA sequencing data revealed the key interactions between immune cells in the melanoma microenvironment. First, differentially expressed genes (DEGs) between normal and malignant tissues were obtained using GEO2R. The DEGs were then subjected to downstream analyses, including enrichment analysis and protein-protein inte

SUBMITTER: Chen J 

PROVIDER: S-EPMC9203818 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature