Itraconazole Reverts ABCB1-Mediated Docetaxel Resistance in Prostate Cancer.

ABSTRACT: Docetaxel (DTX) was the first chemotherapeutic agent to demonstrate significant efficacy in the treatment of men with metastatic castration-resistant prostate cancer. However, response to DTX is generally short-lived, and relapse eventually occurs due to emergence of drug-resistance. We previously established two DTX-resistant prostate cancer cell lines, LNCaP^R and C4-2B^R, derived from the androgen-dependent LNCaP cell line, and from the LNCaP lineage-derived androgen-independent C4-2B sub-line, respectively. Using an unbiased drug screen, we identify itraconazole (ITZ), an oral antifungal drug, as a compound that can efficiently re-sensitize drug-resistant LNCaP^R and C4-2B^R prostate cancer cells to DTX treatment. ITZ can re-sensitize multiple DT

SUBMITTER: Lima TS 

PROVIDER: S-EPMC9203833 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature