Exhausted PD-1⁺ TOX⁺ CD8⁺ T Cells Arise Only in Long-Term Experimental Trypanosoma cruzi Infection.

ABSTRACT: Infection with Trypanosoma cruzi remains the most important neglected zoonosis in Latin America. This infection does not lead to specific symptoms in the acute phase, but chronic infection can result in Chagas disease (CD) with cardiac and/or gastrointestinal manifestations that can lead to death. CD8⁺ T cells are highly effective and essential to control this infection, but fail to eliminate all parasites. In this study, we show that the CD8⁺ T cells are modulated by the transient induction of co-inhibitory receptors during acute infection of C57BL/6 mice. Therapeutic intervention strategies with blocking antibodies only had a marginal effect on the elimination of parasite reservoirs. Only long-term chronic infection gave rise to dysfunctional CD8⁺

SUBMITTER: Galvez RI 

PROVIDER: S-EPMC9203896 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature