K_V 1/D-type potassium channels inhibit the excitability of bronchopulmonary vagal afferent nerves.

ABSTRACT: The K_V 1/D-type potassium current (I_D ) is an important determinant of neuronal excitability. This study explored whether and how I_D channels regulate the activation of bronchopulmonary vagal afferent nerves. The single-neuron RT-PCR assay revealed that nearly all mouse bronchopulmonary nodose neurons expressed the transcripts of α-dendrotoxin (α-DTX)-sensitive, I_D channel-forming K_V 1.1, K_V 1.2 and/or K_V 1.6 α-subunits, with the expression of K_V 1.6 being most prevalent. Patch-clamp recordings showed that I_D , defined as the α-DTX-sensitive K⁺ current, activated at voltages slightly more negative than the resting membrane potential in lung-specific nodose neurons and displayed lit

SUBMITTER: Sun H 

PROVIDER: S-EPMC9203938 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature