Mesial-Temporal Epileptic Ripples Correlate With Verbal Memory Impairment.

ABSTRACT:

Rationale

High frequency oscillations (HFO; ripples = 80-200, fast ripples 200-500 Hz) are promising epileptic biomarkers in patients with epilepsy. However, especially in temporal epilepsies differentiation of epileptic and physiological HFO activity still remains a challenge. Physiological sleep-spindle-ripple formations are known to play a role in slow-wave-sleep memory consolidation. This study aimed to find out if higher rates of mesial-temporal spindle-ripples correlate with good memory performance in epilepsy patients and if surgical removal of spindle-ripple-generating brain tissue correlates with a decline in memory performance. In contrast, we hypothesized that higher rates of overall ripples or ripples associated with interictal epileptic spikes correlate with poor memor

SUBMITTER: Bruder JC 

PROVIDER: S-EPMC9204013 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature