Signatures of Thalamocortical Alpha Oscillations and Synchronization With Increased Anesthetic Depths Under Isoflurane.

ABSTRACT: Background: Electroencephalography (EEG) recordings under propofol exhibit an increase in slow and alpha oscillation power and dose-dependent phase-amplitude coupling (PAC), which underlie GABA_A potentiation and the central role of thalamocortical entrainment. However, the exact EEG signatures elicited by volatile anesthetics and the possible neurophysiological mechanisms remain unclear. Methods: Cortical EEG signals and thalamic local field potential (LFP) were recorded in a mouse model to detect EEG signatures induced by 0.9%, 1.5%, and 2.0% isoflurane. Then, the power of the EEG spectrum, thalamocortical coherence, and slow-alpha phase-amplitude coupling were analyzed. A computational model based on the thalamic network was used to determine the primary neurophy

SUBMITTER: Jiang J 

PROVIDER: S-EPMC9204038 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature