The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine.

ABSTRACT: DNA and RNA methylation dynamics have been linked to a variety of cellular processes such as development, differentiation, and the maintenance of genome integrity. The correct deposition and removal of methylated cytosine and its oxidized analogues is pivotal for cellular homeostasis, rapid responses to exogenous stimuli, and regulated gene expression. Uncoordinated expression of DNA/RNA methyltransferases and demethylase enzymes has been linked to genome instability and consequently to cancer progression. Furthermore, accumulating evidence indicates that post-transcriptional DNA/RNA modifications are important features in DNA/RNA function, regulating the timely recruitment of modification-specific reader proteins. Understanding the biological processes that lead to tumorigenesis or somati

SUBMITTER: Alagia A 

PROVIDER: S-EPMC9204050 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature