CD21^- CD27^- Atypical B Cells in a Pediatric Cohort Study: An Extensive Single Center Flow Cytometric Analysis.

ABSTRACT: Atypical B cells (atBCs) are a distinct B-cell population and represent approximately 5% of B cells in peripheral blood (PB) of healthy adult individuals. However, in adults these cells are expanded in conditions of chronic infections, inflammation, primary immunodeficiencies, autoimmune diseases, and aging. Their immunophenotype is characterized by the lack of CD21 expression and the hallmark human memory B-cell marker CD27. In this study, we investigated the immunophenotype of atBCs in different pediatric pathological conditions and correlated their expansion with the children's clinical diagnosis. We were able to retrospectively evaluate 1,571 consecutive PB samples, corresponding to 1,180 pediatric patients, by using a 9-color flow-cytometric panel. The results, compared with a pediatr

SUBMITTER: Corrente F 

PROVIDER: S-EPMC9204099 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature