APOE ε4 Allele Distribution and Association With Scores of Subjective Cognitive Decline Questionnaire 9 in a Large Chinese Memory Clinic Cohort.

ABSTRACT:

Background

Previous reports on APOE ε4 allele distribution in different populations have been inconclusive. The Subjective Cognitive Decline-Questionnaire 9 (SCD-Q9) was developed to identify those at risk of objective cognitive impairment [OCI; including mild cognitive impairment (MCI) and dementia groups), but its association with APOE ε4 and discriminatory powers for SCD _{with subtle cognitive decline} (SCDs) and OCI in memory clinics are unclear.

Objectives

To investigate demographic distribution of APOE ε4, its association with SCD-Q9 scores, and its ability to discriminate SCDs and OCI groups from normal control (NC).

Methods

A total of 632 participants were recruited (NC = 243, SCDs = 298, OCI = 91). APOE ε4 allele di

SUBMITTER: Hao L 

PROVIDER: S-EPMC9204235 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature