B Cells Are Required to Generate Optimal Anti-Melanoma Immunity in Response to Checkpoint Blockade.

ABSTRACT: Immunotherapies such as checkpoint blockade therapies are known to enhance anti-melanoma CD8⁺ T cell immunity, but only a fraction of patients treated with these therapies achieve durable immune response and disease control. It may be that CD8⁺ T cells need help from other immune cells to generate effective and long-lasting anti-tumor immunity or that CD8⁺ T cells alone are insufficient for complete tumor regression and cure. Melanoma contains significant numbers of B cells; however, the role of B cells in anti-melanoma immunity is controversial. In this study, B16 melanoma mouse models were used to determine the role of B cells in anti-melanoma immunity. C57BL/6 mice, B cell knockout (KO) C57BL/6 mice, anti-CD19, and anti-CXCL13 antibody-treated C57BL/6 mi

SUBMITTER: Singh S 

PROVIDER: S-EPMC9204262 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature